Activity

International Symposium on Glyco-lipidologue

January 21st -22nd, 2020 Umetaro Hall, RIKEN (2-1 Hirosawa, Wako, Saitama 351-0198, JAPAN)

Program

Jan 21st (Tue)

1. Introduction of “Glyco-lipidologue”

9:30-9:40

What is “Glyco-lipidologue”?

Tadashi Suzuki (RIKEN)

2. Special Session: NGLY1-deficiency

9:40-10:00	The race to cure NGLY1-deficiency	Matt Wilsey (Grace Science Foundation (USA)
10:00-10:25	Pathophysiology and therapeutics of NGLY1 deficiency using patient-derived iPSC	Takayuki Kamei（T-CiRA）
10:25-10:50	Animal models for NGLY1 deficiency	Makoto Asahina（T-CiRA）
10:50-11:10	Break
11:10-11:35	Functional genetic interaction between Ngly1 and a lectin-type ubiquitin ligase in mice	Yukiko Yoshida (Tokyo Metro. Inst. Med. Sci.)
11:35-12:05	Genetic Network Analysis of the NGLY1 Pathway	Charles Boone (RIKEN/Toronto Univ. (Canada))
12:05-12:35	Mammalian glycans and glycan-modifying enzymes in immune disease	Nan Yan (UT Southwestern (USA))
12:35-14:00	Lunch
14:00-15:40	Poster Session Presentation Core time: Odd number: 14:00-14:50 Even number: 14:50-15:40

3. Clarification of functions of glycans/lipids

15:40-16:05	Enzyme promiscuity in deciphering novel glycol- & lipid functions	Yoshio Hirabayashi (RIKEN)
16:05-16:30	Lipid-based mechanisms for axon guidance	Hiroyuki Kamiguchi (RIKEN)

16:30-17:15	Glycosylphosphatidylinositol: glycan and phospholipid in one molecule	Taroh Kinoshita (Osaka Univ.)（Special Lecture）
18:00-20:00	Get together party (fee applied; 3,000 JPY/person)	Hirosawa Club, RIKEN

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January 22nd (Wed)

4. Mass Spectrometry, database and beyond

10:00-10:25	LipidBank database	Masanori Arita (RIKEN/Natl. Inst. Genet.)
10:25-10:50	The GlyCosmos Portal for integrating glycoconjugate data	Kiyoko Aoki-Kinoshita (Soka Univ.)
10:50-11:10	Break
11:10-11:40	Mass spectrometry for comprehensive glycomics in biomedical research	Kazuhiro Aoki (CCRC, Univ. Georgia (USA))
11:40-12:05	Advanced lipidomics to unveil the potential link between lipid metabolism and biological phenotypes	Makoto Arita (RIKEN/Keio Univ.)
12:05-13:30	Lunch

5. Innovative tool/methods for Glyco-lipidologues

13:30-13:55	Therapeutic in vivo synthetic chemistry: Metal-catalyzed cell surface glycosylation	Katsunori Tanaka (RIKEN/Tokyo Inst. Technol.)
13:55-14:20	Lipid regulation of membrane receptor proteins	Yasushi Sako (RIKEN)
14:20-14:50	Imaging cholesterol	Toshihide Kobayashi (Univ. Strasbourg (France))
14:50-15:10	Break

15:10-15:35	Molecular dynamics of membrane protein dynamics and stability	Yuji Sugita (RIKEN)
15:35-16:05	Toward glycan binding site prediction	Wonpil Im (LeHigh Univ. (USA))
16:05-16:35	NMR analysis of glycolipid in aqueous solution	Yoshiki Yamaguchi (Tohoku Med. Pharm. Univ.)

Poster Session (3rd Floor)

From the Umetaro Hall, please take stairs/elevator located right next to the hall to get to the 3rd floor, where you will find poster boards.
Poster will be presented from the start of the symposium until 15:10, January 22nd (end of the afternoon coffee break).

List of posters:

1: EGF stimulation dissociates EGFR from phosphatidylinositol-4,5-bisphosphate membrane domain

Mitsuhiro Abe, Masataka Yanagawa, Yasushi Sako

2: Video-recording of crawling motion of 1,000 C. elegans individuals during lifespan

Yukinobu Arata, Yusaku Ikeda, Peter Jurica, Yasushi Sako

3: Towards in vivo gold (III)-catalyzed chemical glycosylation for targeting cancer cells

Tsung-Che Chang, Yixuan Lin,,Katsunori Tanaka

4: Physiological function of Ngly1 in the liver

Haruhiko Fujihira,Yuki Masahara-Negishi, Yoshihiro Akimoto, Hiroto Hirayama, Hyeon-Cheol Lee, Benjamin A. Story, William F. Mueller, Petra Jakob, Sandra Clauder-Münster, Lars M. Steinmetz, Senthil K. Radhakrishnan, Hayato Kawakami, Yoshihiro Kamada, Eiji Miyoshi, Takehiko Yokomizo, Tadashi Suzuki

5: Probing the Ligand Binding Pocket of GPR 55

Adam.T. Guy, Koki Kano, Yukishige Ito, Yoshio Hirabayashi, Hiroyuki Kamiguchi, Ichiro Matsuo, Peter Greimel

6: Studies on the serum sialyl oligosaccharides

Chengcheng Huang, Junichi Seino, Haruhiko Fujihira,Tadashi Suzuki

7: Evaluation of the acyl-migration reaction of lyso-phosphatidyl-β-D-glucoside

Koki Kano, Ayumi Kuroiwa, Peter Greimel, Ichiro Matsuo

8: Toward identification of a novel dolichol-linked oligosaccharides pyrophosphatase

Shengtao Li, Takehiro Suzuki, Naoshi Dohmae, Tadashi Suzuki

9: In vivo prodrug activation using gold(III)-catalyzed hydroamination

Yixuan Lin, Tsung-Che Chang, Katsunori Tanaka

10: Lipid-cholesterol-protein interaction in the dimerization of juxtamembrane domains of epidermal growth factor receptor

Ryo Maeda, Takeshi Sato, Yasushi Sako

11: Synthesis of N-glycans based on the regioselective glycosylation and simultaneous inversion reaction of stereochemistry of hydroxyl groups

Mitsuo Nagata, Tomomichi Takagaki, Kanae Sano, Ichiro Matsuo

12: Role of the Transmembrane Region in FGFR3 Activation examined through Enhanced Sampling Simulation

Daisuke Matsuoka, Yuji Sugita

13: Isolation of a bacterium capable of utilizing C-mannosyl tryptophan as a carbon source

Ken-ichi Moto, Shino Manabe, Tanim J. Hossian, Yukishige Ito, Tadashi Suzuki

14: Intra-nuclear lipid transport in baculovirus-infected cells

Toshihiro Nagamine, Yasushi Sako

15: Construction of library for PA-labeled high mannose type glycans

Junichi Seino, Haruna Tomotake, Yoichiro Harada, Yoichi Takeda, Akira Seko, Kiichiro Totani, Ichiro Matsuo, Yukishige Ito, Tadashi Suzuki

16: Quantitative analysis of lipid classes and their molecules utilizing supercritical fluid chromatography

Hiroaki Takeda, Yoshihiro Izumi, Masatomo Takahashi, Adam T. Guy, Koki Kano, Ichiro Matsuo, Takeshi Bamba , Hiroyuki Kamiguchi

17: MS-DIAL 4: handling lipidomics data using retention time, CCS, and MS/MS atlas

Hiroshi Tsugawa, Kazutaka Ikeda, Mikiko Takahashi, Aya Satoh, Yoshifumi Mori, Haruki Uchino, Nobuyuki Okahashi, Yutaka Yamada, Ipputa Tada, Paolo Bonini, Yasuhiro Higashi, Yozo Okazaki, Zhiwei Zhou, Zheng-Jiang Zhu, Jeremy Koelmel, Tomas Cajka, Oliver Fiehn, Kazuki Saito, Masanori Arita, Makoto Arita

18: Single-molecule imaging based estimation of multiple drug effects on GPCR

Masataka Yanagawa, Michio Hiroshima, Mitsuhiro Abe, Masahiro Ueda, Yasushi Sako

19: Establishment of a new animal model of NGLY1 deficiency in rats

Reiko Fujinawa, Makoto Asahina, Hiroto Hirayama, Ryuichi Tozawa , Tadashi Suzuki

20: Establishment of NGLY1 activity assay and study of enzyme properties of NGLY1 mutants identified from patients of NGLY1-deficiency

Hiroto Hirayama, Yuriko Tachida, Tadashi Suzuki

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This symposium is financially supported by RIKEN library and Mizutani Foundation for Glycoscience.